abstract：:Azaperone was evaluated for its mutagenic potential by the Salmonella/microsome test. No mutagenic activity towards six S. typhimurium strains could be evidenced with azaperone at doses up to 2,000 micrograms/plate, either without or with metabolic activation at usual test conditions. Higher concentrations of liver po...

journal_title：Drug and chemical toxicology

authors： Duverger-van Bogaert M,Vanparys P,de Meester C,Marsboom R

更新日期：1987-01-01 00:00:00

abstract：:Three trials involving 184 male Sprague Dawley rats were conducted to identify the biologically active fraction of endophyte-infected tall fescue seed. In trial 1, seed infected (greater than 95%) with the endophytic fungus Acremonium coenophialum and shown to be toxic to cattle, was serially extracted with hexane, et...

journal_title：Drug and chemical toxicology

authors： Jackson JA,Hemken RW,Bush LP,Boling JA,Siegel MR,Zavos PM

更新日期：1987-01-01 00:00:00

abstract：:The quantities of selenium, tar and nicotine present in mainstream (MS) and sidestream (SS) smoke of machine-smoked cigarettes was studied. The cigarettes were prepared from tobacco purposely cultured on fly ash-amended soil so as to increase its selenium concentration. Selenium concentration was found to be the same ...

journal_title：Drug and chemical toxicology

authors： Gutenmann WH,Lisk DJ,Shane BS,Hoffmann D,Adams JD

更新日期：1987-01-01 00:00:00

abstract：:The frequency of dexamethasone-induced cleft palate in mouse fetuses was studied at four fixed times on day 13 of gestation. On day 18, the fetuses were examined for malformations and corticosterone concentration was additionally measured. Evidence of a diurnal rhythm in cleft palate frequency, as well as in corticost...

journal_title：Drug and chemical toxicology

authors： Sauerbier I

更新日期：1986-01-01 00:00:00

abstract：:Adult male Sprague Dawley rats were gavaged with 2,4-dinitrotoluene (2,4-DNT) dissolved in corn oil at 0, 60, 180, or 240 mg/kg/day for five days. A single oral dose (0.5 mg/kg) of triethylenemelamine was used as a positive control. Induction of dominant lethal events was scored on the basis of early fetal deaths. At ...

journal_title：Drug and chemical toxicology

authors： Lane RW,Simon GS,Dougherty RW,Egle JL Jr,Borzelleca JF

更新日期：1985-01-01 00:00:00

abstract：:The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weig...

journal_title：Drug and chemical toxicology

authors： Tone JN,Jensen DR

更新日期：1985-01-01 00:00:00

abstract：:Hexachloroethane (HCE) was fed to Fischer 344 rats at approximate doses of 0, 1, 15 or 62 mg/kg/day for 16 weeks. Selected tissues were assayed at termination for HCE content. Histopathological examination identified the kidney as the primary target organ with male rats more sensitive than female rats. The kidney conc...

journal_title：Drug and chemical toxicology

authors： Gorzinski SJ,Nolan RJ,McCollister SB,Kociba RJ,Mattsson JL

更新日期：1985-01-01 00:00:00

abstract：:Hepatic cysteamine and non-protein sulfhydryl (NPSH) levels were determined in galactosamine (GAL)-poisoned rats following hepatoprotective cystamine or cysteamine treatments to determine whether alterations of hepatic NPSH status could contribute to their observed protective actions. D(+)-Galactosamine HC1 (400 mg/kg...

journal_title：Drug and chemical toxicology

authors： MacDonald JR,Gandolfi AJ,Sipes IG

更新日期：1985-01-01 00:00:00

abstract：:This study assessed possible adverse immunological effects of trans-1,2-dichloroethylene (DCE) on random-bred CD-1 mice following 14 and 90 days of exposure. A 14-day range-finding study was performed on male mice by gavage at doses 1/10 and 1/100 the LD50 (210 and 21 mg/kg). No alterations in either humoral or cell-m...

journal_title：Drug and chemical toxicology

authors： Shopp GM Jr,Sanders VM,White KL Jr,Munson AE

更新日期：1985-01-01 00:00:00

abstract：:2-Amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine (ACCPE) is a water soluble compound formed during the alkaline treatment of the alcoholic liquor in the production of 2-chlorobenzylidene malononitrile (CS). The acute toxicity and primary irritancy of ACCPE and CS were investigated and compared. Both perorally and...

journal_title：Drug and chemical toxicology

authors： Ballantyne B

更新日期：1985-01-01 00:00:00

abstract：:The cross-reaction patterns of selected acrylate and methacrylate esters were investigated using the guinea pig maximization test. Methacrylates were less potent sensitizers than acrylates. Cross-sensitization was found between (meth)acrylates with closely related core structures, most extensively between hydroxyethyl...

journal_title：Drug and chemical toxicology

authors： Clemmensen S

更新日期：1984-01-01 00:00:00

abstract：:The median lethal dose (LD50) of chymopapain B in mice was 82 mg/kg (22,000 units/kg) with 95% confidence limits of 75-90 mg/kg (20, 122-24, 146 units/kg) and in rats 92 (24,683 units/kg) with 95% confidence limits of 83-102 mg/kg (22,268-27, 366 units/kg). The mechanism of toxicity was hemorrhage due to destruction o...

journal_title：Drug and chemical toxicology

authors： Simmons JW,Upman PJ,Stavinoha WB

更新日期：1984-01-01 00:00:00

abstract：:The availability of tissue glutathione (GSH) appears to depend upon a balance between tissue concentrations, the rate of reactive metabolite formation and the re-synthesis of GSH. To test this hypothesis, diethyl maleate (DEM, 5.8 mmol/kg bw) was administered intraperitoneally to male and female mice, hamsters, rats a...

journal_title：Drug and chemical toxicology

authors： Ecobichon DJ

更新日期：1984-01-01 00:00:00

abstract：:The disposition of N-[14C-vinyl]-2-pyrrolidinone was studied in male Sprague-Dawley rats following a single iv injection. Plasma levels of the intact compound dropped rapidly within the first 6 hours after dosing with a half life of 1.90 hours. Urinary excretion by 12 hours represented 74.9% of a 5 microCi dose while ...

journal_title：Drug and chemical toxicology

authors： McClanahan JS,Lin YC,Digenis GA

更新日期：1984-01-01 00:00:00

abstract：:In the subchronic study acrylic acid was incorporated in the drinking water of Fischer 344 rats (15 per group) for three months at dosage levels of 0.75, 0.25, 0.083 or 0 g/kg/day. No deaths occurred during the study but several treatment-related effects were observed. At 0.75 g/kg/day dosage level, body weight gain w...

journal_title：Drug and chemical toxicology

authors： DePass LR,Woodside MD,Garman RH,Weil CS

更新日期：1983-01-01 00:00:00

abstract：:A comparison of the fertility and cytogenetic analyses and the combination of both techniques as generally used in the heritable translocation assay was conducted with triethylenemelamine (TEM). CD-1 mice were used as the F0 generation and were divided into two groups that received i.p. either distilled water (control...

journal_title：Drug and chemical toxicology

authors： Moreland FM,Sheu CJ

更新日期：1983-01-01 00:00:00

abstract：:The responses of atria isolated from four groups of rats: (a) control (air/H2O) and test animals treated with (b) 5 PPM nitrogen dioxide NO2 for 72 hours, (NO2/H2O), (c) 10% ethanol (ET) in water for 13 days, (air/ET), or (d) combination of NO2 and ET (NO2/ET). Isolated atria were tested with norepinephrine and dose r...

journal_title：Drug and chemical toxicology

authors： Early J,McGrath J,Messiha FS,Hughes MJ

更新日期：1983-01-01 00:00:00

abstract：:In adult female Wistar rats, pretreated by gavage with two doses - 16 or 256 mumol/kg - of cyanamide, TMTD (tetramethylthiuram disulfide), TMTM (tetramethylthiuram monosulfide), Ziram or Zineb at 90 min or 18 h before administration of 2 g of ethanol/kg i.p., the blood acetaldehyde levels were significantly increased ...

journal_title：Drug and chemical toxicology

authors： García de Torres G,Römer KG,Torres Alanis O,Freundt KJ

更新日期：1983-01-01 00:00:00

abstract：:The tricyclic antidepressant imipramine was instilled directly onto the lung surface of experimental rats in specific low doses (0.025 - 0.60 mg/kg body weight) and the animals were sacrificed at time intervals from 2 - 21 days after a single instillation. Such treatment caused changes almost exclusively confined to t...

journal_title：Drug and chemical toxicology

authors： Lewis RW,Harwood JL,Richards RJ

更新日期：1983-01-01 00:00:00

abstract：:The immunomodulatory effects of two plant regulators, cycloheximide and maleic hydrazide, were investigated by injecting the compounds twice weekly for 4 weeks in female Swiss Webster white mice. The animals were antigenically challenged with sheep red blood cells on day 24 of the study. Although humoral immunity was ...

journal_title：Drug and chemical toxicology

authors： Olson LJ,Hinsdill RD,Weltman DJ

更新日期：1983-01-01 00:00:00

abstract：:As a measure of glutathione (GSH) conjugation, urinary, fecal and biliary excretion of thioethers and hepatic GSH content were measured in rhesus monkeys following administration of single doses of naphthalene and diethylmaleate (DEM). Naphthalene had little or no effect on hepatic GSH content and the excretion of thi...

journal_title：Drug and chemical toxicology

authors： Rozman K,Summer KH,Rozman T,Greim H

更新日期：1982-01-01 00:00:00

abstract：:Various chemical groups were evaluated for their skin sensitization potential in the guinea pig. In general, amines, acetanilides, pyridines, piperidines, and sulfones were positive in the guinea pig test. Since these tests were done over a period of years, any further structural-related correlations or predictions sh...

journal_title：Drug and chemical toxicology

authors： Rao KS,Betso JE,Olson KJ

更新日期：1981-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were administered cadmium chloride 0, 50, 100, 150 and 200 ppm for 30 days. At the end of the treatments, the body weight gains, serum glucose, serum protein, serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were determined. Renal and hepatic key glu...

journal_title：Drug and chemical toxicology

authors： Chapatwala KD,Rajanna B,Desaiah D

更新日期：1980-01-01 00:00:00

abstract：:1-((2-methyl-4-[(2-methyl phenyl)azo] phenyl)azo)-2-naphthalenol (C.I. Solvent Red 24) was prepared having a 14C label on the methyl group of the central ring and was administered in suspension intra-tracheally to a male and a female rat. After 96 hours in metabolism cages, the animals were sacrificed and 14C counted ...

journal_title：Drug and chemical toxicology

authors： Parent RA,Dressler I

更新日期：1979-01-01 00:00:00

abstract：:A toxicity Evaluation of DDT and dieldrin was conducted using Japanese Quail. The effects of feeding DDT (5 and 50 ppm of diet) and dieldrin (0.1 and 1.0 ppm of diet) in this four generation study (parental, F1, F2 and F3) were examined in terms of growth, viability, and/or reproduction of offspring. Ten groups (inclu...

journal_title：Drug and chemical toxicology

authors： Shellenberger TE

更新日期：1978-01-01 00:00:00

abstract：:An automatic system was developed to monitor continuously the colonic temperature of laboratory animals during inhalation exposure to toxic chemicals. It includes: an automatic switchbox, a control circuit, a recorder and a digital voltmeter. The system was calibrated for different temperature ranges and used for a ye...

journal_title：Drug and chemical toxicology

authors： Laham S,Schrader K,Symonds G,Curtin W

更新日期：1978-01-01 00:00:00

abstract：:Eight antineoplastic drugs were evaluated for their ability to induce mutation in the Ames Salmonella/microsome and the TK+/- mouse lymphoma assay. Dose response data were utilized to determine the relative potency of each of these drugs. They were then ranked based on this information. Vincristine, the most potent co...

journal_title：Drug and chemical toxicology

authors： Matheson D,Brusick D,Carrano R

更新日期：1978-01-01 00:00:00

abstract：:The cytotoxic effect of caffeine on heart cells was evaluated in primary cultures of rat heart muscle (M) and endothelioid (E) cells. The cultures were exposed to 5, 10, or 20 mM caffeine for 6, 12, or 24 hours. As an index of cytotoxicity produced by the treatments, in situ changes in mitochondrial membrane fragility...

journal_title：Drug and chemical toxicology

authors： Acosta D,Anuforo D

更新日期：1977-01-01 00:00:00